Home | wisegene

provides exclusive quality reagents, such as:

5hmC/5mC TAB-Array Kit: used to differentiate 5-hydroxylmethylcytosine (5hmC) from 5-methylcytosine (5mC) for subsequent genome-wide 5hmC/5mC detections using Infinium 450K array or other array/enrichment platforms.

5hmC TAB-Seq Kit: to sequence 5-hydroxymethylcytosine (5hmC) at single-base resolution (TAB-Seq: “Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome”, Yu et. al. Cell 2012 149, 1368

5mC Tet1 Oxidation Kit: to efficiently oxidize 5-methylcytosine (5mC) to 5hmC and 5-carboxylcytosine (5caC) (recommended for all other oxidations except 5-hmC TAB-Seq)

Mission Statement

Our mission is to develop, manufacture, and deliver research tools for novel genomic sequencing and detection technology. By working closely with leading academic laboratories, we have and will continue to in-licence, develop and commercialize novel genomic sequencing reagents and methodology in Epigenetics.

Products >

Highlights

Important Note: TAB-seq βGT protection efficiency note

In order to further improve the accuracy of TAB-seq, we have provided a notice on our TAB-seq kit.

To accurately evaluate the protection rate of 5hmC in TAB-seq, we recommend running standard bisulfite sequencing for one sample containing the same batch of 5hmC spike-in control in parallel to determine its real 5hmC abundance. See details here.

News

October, 2016 - Scientists from the Vesalius Research Center at KU Leuven in Belgium have published "Tumor hypoxia causes DNA hypermethylation by reducing TET activity" in Nature which describes the use of Wisgene's TABseq kit; the article is accessible here.